Research Opportunities - Medical Oncology

CP00001 Washington University in St Louis • Full-time • Steven & Susan Lipstein BJC Institute of Health, United States of America • 3w ago

Scheduled Hours

Position Summary

The Miriam Kim Lab studies methods to manipulate immune cells for treatment of hematologic malignancies. We work at the intersection of hematopoiesis, immunology, cancer biology, stem cell biology, and gene engineering.

We are seeking motivated individuals to assist with studies investigating the optimal host environment to support chimeric antigen receptor (CAR) T cell therapy. CAR T cells are genetically engineered immune cells that are used to treat patients with hematologic malignancies such as leukemia, lymphoma and multiple myeloma. While CAR T cell therapy has demonstrated impressive success, many patients do not benefit from treatment, and so we are actively looking for ways to improve outcomes. The successful candidate(s) will conduct preclinical studies using mouse models to assess the effect of immunomodulatory agents on CAR T cell expansion, toxicity and anti-tumor activity and their mechanism of action.

Prior research experience is welcome but not required for this position. The ideal candidate will possess intrinsic motivation to conduct innovative and impactful research. A growth mindset and ability to learn new concepts and skills is essential. The individual will be trained to perform experiments independently and analyze data to produce graphs and figures for publication. Career development opportunities may also be provided.

Routine laboratory techniques in our lab include:

* Isolation of primary immune cells from human and mouse samples, including monocytes, T cells, B cells, NK cells, and hematopoietic stem cells.
* Genetic manipulation of immune cells using lentivirus, retrovirus, and/or CRISPR/Cas9-based gene editing.
* Flow cytometry including sample preparation, acquisition and data analysis.
* Mouse husbandry and small animal procedures.

Job Description

Primary Duties & Responsibilities:

More details of our research can be found here: https://miriamkimlab.com.

Working Conditions:

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range:

Base pay is commensurate with experience.

Applicant Special Instructions:

Please submit the following when applying: 1) one-page cover letter briefly describing your research interests and career goals, 2) curriculum vitae, and 3) contact information of 2-3 references.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Bachelor’s degree or combination of education and/or experience may substitute for minimum education.

Certifications:

No specific certification is required for this position.

Work Experience:

No specific work experience is required for this position.

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

Candidates with additional education and experience are encouraged to apply.

Preferred Qualifications

Education:

No additional education beyond what is stated in the Required Qualifications section.

Certifications:

No additional certification beyond what is stated in the Required Qualifications section.

Work Experience:

No additional work experience beyond what is stated in the Required Qualifications section.

Skills:

Communication, Laboratory Research, Organizing, Recordkeeping, Working Independently

Grade

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.Washington University is dedicated to building a community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

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